Impact of Clinical Pharmacist Driven Adverse Drug Reaction Profile in Schizophrenia Patients on Atypical Antipsychotics at A Tertiary Care Setting

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Sangaokar D G
Kamble N A
Ahamad T

Abstract

Introduction: Schizophrenia is one of the most serious and frightening of all mental illnesses. Atypical antipsychotics are
first line drugs for schizophrenia. They have significant adverse drug events. Aim: The study was conducted with an aim
to evaluate the pattern of occurrence of Adverse Drug Reactions (ADRs) in the patients with schizophrenia and to assess
their causality and severity. Materials and Methods: A prospective study was carried out in the psychiatry inpatient and
outpatient department of KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belagavi, Karnataka for 3
months. All patients diagnosed with schizophrenia and stable on atypical antipsychotics and receiving pharmacotherapy
was included. Assessment of causality and severity of recorded ADRs was done using Naranjo’s scale and Hartwig Scale
respectively. Results: A total 32 ADRs were recorded from 25 patients out of 60 patients. The most common ADRs were
weight gain (28.13%) and insomnia (18.75%). Majority of ADRs were Probable (53.13%)on Naranjo’s causality
assessment scale and Level 4b (40.63%) on Hartwig’s severity assessment scale. The drug Aripriprazole showed maximum
ADRs (34.38%). Conclusion: ADRs are frequent occurrence in patients with schizophrenia which are probable in most
cases. Incidence of ADRs can be decreased and compliance as well as quality of patient can be improved by early detection
and management.

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How to Cite
D G, S., N A, K., & T, A. (2019). Impact of Clinical Pharmacist Driven Adverse Drug Reaction Profile in Schizophrenia Patients on Atypical Antipsychotics at A Tertiary Care Setting. International Journal of Pharmaceutical and Clinical Research, 11(04), 94-100. Retrieved from http://ijpcr.com/index.php/ijpcr/article/view/637
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Research Article