Monthly Publishing Peer Reviewed Journal


Notice: "doi number" allotment has been started for present and past manuscripts


Volume10,Issue3

1. A Study to Assess the Knowledge on Autism Among Parents Attending At SRM General Hospital, Kattankulathur
Abirami P, Rubak Vijay G, G Usha, M.  Mareeswari
Abstract
Objective: The aim of this study was to assess the knowledge on autism among parents and to associate the knowledge on autism among parents with their demographic variables and clinical variables. Methods: Quantitative approach and non-experimental descriptive research design was used. The data collection included two parts. Part A: Demographic variables, Part B: A Structured questionnaire to assess knowledge on autism among the parents. 50 parents who fulfilled the inclusion criteria were selected as samples using non probability convenient sampling technique. The study was conducted at SRM General Hospital,Kancheepuram dt. Results: The data were analyzed and interpreted based on the objectives using descriptive and inferential statistics. Among 50 parents , 26 (52%) parents have moderately adequate knowledge, 21 (42%) parents have inadequate knowledge, 3 (6%) parents have adequate knowledge and there is no significant association on knowledge on autism with their demographic variables. Conclusion: The future of any society depends on its children. Parents are laying the foundation for their child’s lives. Parents must be supported, included as the primary caretaker and teacher of the child, and also give proper information about the care, disease condition and commercially available devices that can aid in achievement of independence of their children

2. In silico Docking Studies of Secondary Metabolites from Marine Sponge Discodermia calyx – Natural Inhibitor for Breast Cancer
Jaynthy C, Shanmugalakshmi G, Anusha Mathan B
Abstract
Objective: The present study is concerned with the docking of secondary metabolites of marine sponge Discodermia calyx and their application as anticancer agent in order to arrive at an effective drug like molecule targeting the Human Estrogen Receptor alpha (ERα) mainly responsible for Breast Cancer. Method:  The tools and software used are Protein Data Bank, to retrieve the structure of the protein; Pubchem compound database, to retrieve the chemical structure of the Estrogen Receptor inhibitors, Discovery Studio2.0 for pharmacophore and the docking analysis. Result: The results show that the compounds Cis-3,4- Dihydrohamacanthin B, Deoxytopsentin, Isobromodeoxytopsentin, Bromodeoxytopsentin, Ent kurospongin are more favourable to bind with Glutamic acid353 (GLU 353), the amino acid present in the active site of the protein. Conclusion: Docking analysis reveals that among five compounds Cis-3,4- Dihydrohamacanthin shows good binding affinity with the active site of the Human Estrogen Receptor protein and can be used as a potential Estrogen Receptor inhibitor.

3. Recent Advancements in  Transdermal Drug Delivery System
Priyanka M PawarKinjal P. Solanki, Vipul A Mandali
Abstract
Transdermal drug delivery is one of the most promising methods for drug application. The administration of drugs by transdermal route offers the advantage of being relatively painless. Drug delivery with Transdermal patch systems exhibit slow, controlled drug release and absorption. Controlled drug delivery can be achieved by transdermal drug delivery system which can deliver the drug through skin to the systemic circulation at a predetermine rate over a prolonged period of time. Skin penetration enhancement technique have been developed to improve the bioavailability and increase the range of drug for which the transdermal and topical route is viable option. Characterization of transdermal patch is use to check it’s quality, size, time of onset & duration, adhesive property, thickness, weight of patch, moisture of content, uniformity & cutaneous toxicological studies. The market for transdermal products has been in a significant upward trend that is likely to continue for the foreseeable future.

4. The Cluster Analysis of Indonesian Coffee at Two Different Brewing Temperature Using FTIR-ATR (Fourier Transform Infrared –Attenuated Total Reflectance) Method Coupled with Chemometrics
Winingsih W, Firmansyah A, Soebara Y S
Abstract
Coffees is an agricultural commodity that widely cultured at different region in Indonesia. From all Indonesian coffees, the best known coffee are from Aceh Gayo, Flores, Kintamani, Mandheling, Papua, Sidikalang, Toraja, Kerinci and Lampung. Those coffees have characteristic flavor that can only distinguish by the expert coffee taster.  This study attempts to classify nine types of Indonesian coffee, therefore the different of those coffees tastes were studied from chemical aspect. For such purposes, the Fourier Transform Infra Red (FTIR) combined with chemometrics was used. In this case, FTIR was used to classify the coffees from various regions in Indonesia. The classification was conducted to the filtrate and residue of nine Indonesian coffees that was brewed at two different temperatures. The coffees samples studied were taken from nine regions in Indonesia, namely Aceh Gayo, Flores, Kintamani, Mandheling, Papua, Sidikalang, Toraja, Kerinci and Lampung. The chemometrics model used was principals component analysis (PCA) and cluster analysis (CA). From this study, the classification and similarities among the coffees that were brewed at two different temperatures can be known.

5. Assessment of Knowledge on Control and Prevention of Zika Fever Among B.Sc Nursing Students at SRM College Of Nursing
Sujatha Thulukkanam
Abstract
Objective: The aim of this study was to assess the knowledge on prevention and control of Zika fever among Nursing and to associate the level of knowledge on control and prevention of Zika fever with their selected demographic variables of the Nursing students. Methods: Quantitative approach and non-experimental descriptive research design was used. The data collection included two parts. 180 students who met the inclusion criteria for the study were selected by using non-probability purposive sampling technique. Structured questionnaire of knowledge on control and prevention of Zika fever was derived by the investigator. The study was conducted at SRM College of Nursing among 180 B.Sc. Nursing students. Results: The data were analyzed and interpreted based on the objectives using descriptive and inferential statistics . The findings depicted that majority 75.0% of them are having inadequate knowledge, 24.4% of them are having moderate knowledge and 0.6% of them are having adequate knowledge on control and prevention of Zika Fever. There was no significant association found between the Knowledge level on Control and Prevention of Zika fever among B.Sc Nursing students. Conclusion: Zika Fever is a major global concern as no cases have been estimated in Asian countries and even in India. So, due to lack of treatment modalities, having knowledge and awareness on control and prevention about this disease can help in saving lives and also help in stopping the spread of Zika fever widely. The investigator concludes that, awareness among nursing students is very poor. Hence, education among nursing students is needed.