1. Paclitaxel Loaded Magnetic Nanoparticles Induce In vivo Tumor Growth Inhibition in a Rat Glioblastoma Model. Ramulu Chintala, Fahima Dilnawaz, Manas Panigrahi, Sanjeeb K. Sahoo, Phanithi Prakash Babu
Glioblastoma multiforme (GBM) is one of the most common and lethal diseases and the current therapeutic options remain sparse. The magnetic nanoparticles (MNPs) based drug delivery approach for the cancer treatment has become one of the promising options to achieve controlled drug delivery to target tumor. In the present study the efficacy of paclitaxel loaded glyceryl monooleate (PAC-GMO)-MNPs was evaluated by administering it in a glioblastoma induced rat model. The results of H&E and immunohistochemistry (IHC) suggest that the treatment with PAC-GMO-MNPs significantly reduced or inhibit the tumor growth as compared to the native drug and may be the potential vehicle for efficiently treating GBM.
2. Effectiveness of Structured Physical Activity Intervention on Physical Activity and Body Mass Index Among Adolescents – A Pilot Study Sumathy.P
Introduction: Adolescence is a period of transition from childhood to adulthood, that assumes critical position in the life cycle of human beings. The International Association for the Study of Obesity (IASO) and International Obesity Task Force (IOTF) estimate that 200 million children are either overweight or obese. The main reasons cited are poor dietary habits, inadequate physical activity and increased sedentary behavior. The study was primarily undertaken to assess the Effectiveness of Structured Physical Activity Intervention on Physical Activity and BMI among adolescents. Materials &Methods: A Quantitative research approach with a pre experimental research design was adopted for the study. 30 samples in the age group of 11-14 years were selected by non-probability purposive sampling technique. The study was conducted in a Private English High School, Puducherry Physical Activity Questionnaire- Older Children (PAQ-C)was used to collect the data. Paired t test was used to analyze the data. Results: The results showed that 66.66% of the adolescents engaged in low levels of physical activity. After the structured physical activity practiced by the children for a period of one month the levels of physical activity engaged by the children have been improved which was statistically significant at p<.05 and the mean BMI in posttest was 23.46kg/m2when compared to pretest BMI which was 23.6kg/m2. Conclusion:The study findings reveal that children who are overweight are less likely to engage in physical activity. There is an utmost need that children should engage in at least 60 minutes of physical activity daily which would definitely prevent overweight and obesity and improve their cardio-metabolic status.
3. Valsartan – A Review of Analytical Methods S.Alexandar, M. Kumar
This review focuses on the recent developments in analytical techniques for estimation of Valsartan alone or in combinations with other drugs in various biological media like human plasma and urine. This review will critically examine the analytical methods UV Spectroscopy, high performance liquid chromatography (HPLC), ultra performance liquid chromatography (UPLC), high performance thin layer chromatography (HPTLC), liquid chromatography coupled to tandem mass spectrometry (LC-MS).
4. Study of Anti-epileptic Drugs on Cognitive Parameters in Patients with Epilepsy. P. R Anand Vijayakumar, Reima Elizabeth Jacob, Ritty Augustine,Rasmi Raj,Chennupati Rohith
Background:In the management of epilepsy, classic Anti-Epileptic Drugs(AEDs) has been observed to produce a significant effect than classic AEDs on cognition. Purpose of the Study: To compare the prevalence of cognitive impairment in patients with epilepsy receiving newer and classical AEDs. Methods: This study is a cross-sectional observational study, with the intention of studying point prevalence of adverse cognitive effect of antiepileptic treatment.The MMSE scale was used to assess the cognitive function. The data obtained were analyzed using IBM SPSS Statistics 21 and Graph Pad Prism version 7.03 Result: It was found that patients on AEDs for more than 10 years and on poly-therapy were having the least MMSE scores implying more cognitive impairment. Among Various domains of MMSE assessed, it was found that orientation and language &visuospatial skill were the significantly affected domains in patients receiving poly-therapy. Conclusion: Patients on poly-therapy with Classic AEDs had more cognitive impairment when compared to poly-therapy with Newer AEDs and combination of Classic AED and Newer AED.
5. Phytochemical Screening and Antimicrobial Activity of Herbal Plant Extracts- Achyranthus aspera
The plant species Achyranthes aspera from the family Amaranthaceae is a vital healthful and medicated herb found throughout in India. Although most of its components are employed in ancient systems of medicines such as seeds, roots and shoots are foremost necessary components that are used for treatment of disease. The article provides associate degree account on updated info about phyto-chemical and anti-microbial activity. Chloroform and methyl alcohol root and shoot extracts of A. aspera showed sensible quantity of medication activity against enterobacteria sp. Root extract showed the activity against B. Substilis solely antifungal activity of roots was found in extracts with petroleum ether, chloroform and methyl alcohol against fusarium sp. Phytophothora and Sclerouum sp. Results recommend that extract has important medication and antifungal activities against tested microorganisms.