International Journal of

Pharmaceutical and Clinical Research

e-ISSN: 0975 1556

p-ISSN 2820-2643

Peer Review Journal

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1. Qualitative and Quantitative Analytical Studies for the Screening of Phytochemicals from the Leaf Extracts of Senna alexandrina Mill.
Leelavathi V, Udayasri P
The increasing resistance to the existing synthetic drugs is being substituted with the alternative herbal drugs as an importance source of new agents for treating various ailments. Senna alexandrina Mill. is a well known plant in Asian countries including India, which exhibits a wide range of pharmacological activities. It has been used in Indian folk medicine in the form of decoctions and infusions to treat bacterial infections and was also reported to be an effective against a variety of skin diseases. The current investigation was carried out to explore the phytochemical components of the selected plant by performing preliminary biochemical and quantitative analysis by employing UV-visible spectroscopy. The crude extracts were scanned in the UV wavelength ranging from 200-800nm by using Perkin Elmer Spectrophotometer and the results indicate that alkaloids, flavonoids carbohydrates, proteins and saponins are the more prevalent components in the methanolic and ethyl acetate extracts of Senna alexandrina leaf.

2. Evaluation of Quercetin and Chrysin for Anthelmintic Activity Using Adult Indian Earthworm Model
Sheethal Shinde, Divya Rayapureddy, Naveen Babu Kilaru, Ravindrababu Pingili
Objective: Helminths infections are also among the most common infections in human, affecting a large proportion of the world’s population in developing countries and produce a global burden of disease. Pherithema posthuma a helminthes is commonly known as earth-worms. Quercetin and chrysin are the flavonoids, which were evaluated for the anthelminthic activity using Pheretima posthuma model (Indian earthworm). Albendazole was used as the standard reference. Methods: Four concentrations (10, 20, 30 and 40 mg/ml) of these flavonoids were used for this study which involved the determination of time of paralysis (vermifuge) and time of death (vermicidal activity) of the worms. Results: Chrysin not only paralyzed but also killed the earthworms dose-dependently but Quercetin not showed any paralytic effect (i. e. animals are alive). Chrysin showed maximum vermicidal activity at the concentration of 40 mg/ml followed by 30 mg/ml. Observations were comparable with the standard drug at concentration of 20 mg/ml. Conclusion: On the basis of the observations it is concluded that Chrysin has a significant anthelminthic activity when compared to the Quercetin.

3. Development and Validation of Analytical Method for Simultaneous Estimation of Bisoprolol Fumarate and Telmisartan by Using RP-HPLC Method
Barge V U, Gaikwad R B, Chaudhari F M,  Kande T R
A simple, rapid and selective HPLC method has been developed for quantitation of Bisoprolol fumarate and Telmisartan from bulk drug and pharmaceutical formulations using a mobile phase consisting mixture of methanol and water (75:25 v/v) at the flow rate of 1ml/min. An Waters X Bridge RP C18 (4.6 x 250 mm) column was used as stationary phase. The retention time of Bisoprolol fumarate and Telmisartan were 5.7 min. and 7.6 min. respectively. Linearity was observed in the concentration range of 5-25 μg/ml for Bisoprolol fumarate and 40-200 μg/ml for Telmisartan. Percent recoveries obtained for Bisoprolol fumarate and Telmisartan were 99-101 % and 99-100 % respectively. The proposed method is precise, accurate, selective and rapid for the simultaneous determination of Bisoprolol fumarate and Telmisartan.

4. Review on  Medicinal Herbs Used for Diabetes
Narhe Sonal ,Kshirsagar Sandip S, Patil Vishal S
ln the last few years, there has been an exponential in the field of herbal medicine and gaining popularity both in developing and developed countries because of their natural origin and less side effect. A comprehensive review was conducted to pile up information about medicinal plants used for the treatment of diabetes mellitus. lt is a metabolic disorder of the endocrine system and affecting nearly 10% of population  all over the world also the number  of those affected is increasing day to day. Medicinal plant used to treat diabetic condition are of considerable interest and a number of plant have shown varying degrees of hypoglycemic and anti-hyperglycemic activity. The wealth of tribal knowledge on medicinal plant point to great potential for research and the discovery of new drugs to fight diseases including diabetes, obtaining new foods and other new uses. There are lots of chemical agents available to control and to treat diabetic patients, but total recovery from diabetes has not been reported up to this date. Several medicinal plants have been investigated for their beneficial use in different types of diabetes. A considerable number of plants were subjected to clinical trials and were found effective. Moreover, during the past few years many phytoconstituent responsible for anti-diabetic effect have been isolated from hypoglycemic plants. This paper focus mainly on diabetes, plants used as anti-diabetic in various traditional medicines, constituents isolated from these plants, various mechanism through which herbs act against diabetes and few examples of anti-diabetic formulation available in the market.

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