Helminths infections are also among the most common infections in human, affecting a large proportion of the world’s population in developing countries and produce a global burden of disease. Pherithema posthuma a helminthes is commonly known as earth-worms. Quercetin and chrysin are the flavonoids, which were evaluated for the anthelminthic activity using Pheretima posthuma model (Indian earthworm). Albendazole was used as the standard reference. Methods:
Four concentrations (10, 20, 30 and 40 mg/ml) of these flavonoids were used for this study which involved the determination of time of paralysis (vermifuge) and time of death (vermicidal activity) of the worms. Results:
Chrysin not only paralyzed but also killed the earthworms dose-dependently but Quercetin not showed any paralytic effect (i. e. animals are alive). Chrysin showed maximum vermicidal activity at the concentration of 40 mg/ml followed by 30 mg/ml. Observations were comparable with the standard drug at concentration of 20 mg/ml. Conclusion:
On the basis of the observations it is concluded that Chrysin has a significant anthelminthic activity when compared to the Quercetin.