Introduction: Hernia repair is one of the most common operations performed by general surgeons worldwide. Despite the frequency of this procedure, no surgeon has ideal results and complications such as those related to mesh repair and those related to without mesh repair such as post operative pain, nerve injury, seroma, surgical site infection, chance of recurrence with time and CGPS (Chromic Groin Pain Syndrome) suggest that hernia is a chronic disease process effecting Patients over their lifetime. The aim of present study is to compare gold standard technique of Lichtenstein’s Hernioplasty versus Desarda’s biological repair (Both by open technique) in our Medical College. Materials and Methods:  This double blinded randomised controlled study was conducted with a total of sixteen patients, including eight patients who underwent Lichtenstein’s Hernioplasty using polypropylene mesh and another eight patient underwent Desarda’s biological repair using absorbable suture material, vicryl. Using Inclusion and exclusion criteria–All the patients who underwent surgery by either method were followed up closely for eight months, possible complications and the data was recorded, analysed and synthesised narratively. Results:  Considering population sample size and age of the sample; Mean-SD were calculated. The mean for the entire sample is 39.875 and SD is 3.332; variance is 1.825; co-efficient of variation is 8.356

	Mean	SD	Variance	CV
Lichtenstein’s	39.375	3.079	1.754	7.819%
Desarda’s	40.375	3.466	1.861	8.584%

Again, two sample paired t-test is located weather the mean of the population has a value specified in null hypothesis. t= ; Degree of freedom is n-1. By the central limit theorem; if the observations are independent and the second moment exists, then it will be approximately normal N (0-1).bHere values of student t-tests are 0.897 (total sample). Study quality is assessed by oxford quality rating scale (JADAD SCALE). Yielding two points for randomisation, one for double blinding and one for dropout rate: 4/5; suggesting high quality. However, it does not include an assessment item for allocation concealment. As a result of the growing influence of evidence based medicine Heterogeneity value is taken nil-significant (all patients from the same geography).Above data shows Mean SD of the Desarda’s group is slightly higher than Lichtenstein’s, but the difference was statistically not significant. Conclusion: Present study suggests that uncomplicated hernia repairs by means of Desarda’s technique are relatively pain free yielding the same success rate as that of Lichtenstein’s and obviously not carrying complications of mesh repair (Hernioplasty). However, O.R. time is more and also considering the limited sample size, same geographical pattern sampling- large sample size may be required to be studied along with long duration follow up as well.

DOI: 10.5281/zenodo.

Objectives: The present study was to evaluate and compared the serum levels of gamma-glutamyl transferase, aspartate aminotransferase (AST), alanine transaminase (ALT), AST: ALT, and bilirubin in patients with chronic Hepatitis with control. Methods: A detailed history of all the participants was taken on a pre-designed questionnaire. For the evaluation of blood serum GGT, AST, ALT, AST:ALT ratio, and bilirubin, 5 ml blood sample was withdrawn from the anticubital vein of all participants and were collected in a sterile, dry, and plain vial. The serum utilized in the estimation of biochemical assays was separated from the blood sample by centrifugation at 3000 rpm for 10 minutes. The IFCC method was used to estimate the serum levels of the parameter using a commercially available kit from Transasia Pvt. Ltd. The tool used was an ERBA 5 chem semi-auto analyser. Results: A total of 50 chronic hepatitis patients were enrolled in a case group and 50 healthy individuals were included as control group. Mean age of the patients in case group was 50 ± 12.87 years. And mean age of healthy individual in control group was 48 ± 14.76 years.  In case group, males were 37(54%) and females were 23(46%). And in control group, males were 28(56%) and females were 22(44%). When we compared the Gamma-glutamyl transferase between case and control. which was highly significant differences (P<0.0001). Similarly other enzymes such as Aspartate aminotransferase, Alanine transaminase, and AST: ALT were also highly significant differences (P<0.0001) between cases and control. Serum level of Bilirubin was also highly significant differences (p<0.0001) in case as compared to control subjects. When we  correlated the different parameter of chronic hepatitis patients. GGT level was not significant differences (p=0.868). ALT level was highly significant differences (p<0.000). AST level (P=0.000), AST: ALT ratio (P=0.020) and bilirubin level was significant differences (P=0.012). Conclusions: Gamma-glutamyl transferase, Aspartate aminotransferase, Alanine transaminase, AST: ALT ratio and serum level of bilirubin was extreme significantly higher in patients with chronic hepatitis as compared to control (healthy subjects). Hence, GGT, AST, ALT, AST:ALT ratio, and bilirubin, are prominent indicators of chronic hepatitis.

DOI: 10.5281/zenodo.