Background: Drug resistance persists in certain patients with epilepsy, despite the fact that it has long been regarded as one of the most common nervous system disorders. Centella asiatica has been used to treat epilepsy in traditional medicine. The antiepileptic efficacy of Centella asiatica was studied in a pentylenetetrazole (PTZ)-induced epilepsy model in order to develop an antiepileptic medication with minimal side effects.
Methods: For the purpose of eliminating the gender component, 48 lab-bred female mice were divided into 6 equal groups for this experimental study. The experimental groups included control, standard, and four treatment groups that received the extract 30 minutes prior to PTZ injection at doses of 50, 100, 150, and 200 mg/kg (intraperitoneally). The frequency of epileptic symptoms and their contributing factors were also examined.
Result: The mice in the 50 mg/kg dosing group showed the highest incidence of epileptic attacks, according to the results of utilising various doses of the extract. Myoclonic twitches were more common in samples that received the extract at doses of 50 and 200 mg/kg, respectively. The group that received a dose of 200 mg/kg experienced an increase in epileptic symptoms, a decrease in epilepsy frequency, and a drop in the death rate (p<0.05).
Conclusion: Based on the results, a 200 mg/kg dose of Centella asiatica extract may be suggested as a medication that effectively prevents epilepsy in the animal model.