Day by day there are new developments in field of colon specific drug delivery system. Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the treatment of local diseases associated with the colon like Crohn’s disease, ulcerative colitis, etc but also for the systemic delivery of proteins, therapeutic peptides, anti-asthmatic drugs, antihypertensive drugs and anti-diabetic agents. New systems and technologies have been developed for colon targeting and to overcome pervious method’s limitations. Colon targeting holds a great potential and still need more innovative work. This review article discusses, in brief, introduction of colon, factor effecting colonic transition, colonic diseases and the novel and emerging technologies for colon targeting.

In recent years, indole derivatives have acquired conspicuous significance due to their wide spectrum of biological activities. It is well known fact that the indole nucleus is present as a structural unit in many natural products. Synthesis and biological evaluation of indole derivatives have been a topic of special interest to organic and medicinal chemists. A number of indole derivatives have been reported and widely identified as a privileged structure of pharmacophore with representation in over 3000 natural isolates and are known to possess broad spectrum of biological and pharmaceutical activities.

Pomegranate (Punica granatum), a small tree originating in the orient, belongs to the Punicaceae family. P. granatum is grown mainly in Iran, India and the USA, but also in far East countries. The most important use of P. granatum is as table fruit, but large amounts are used in the beverage and liquor industries. The pericarp, containing up to 30% tannins, is used in tanning leather. In Sanskrit it is known as “Dadima”, and Hindi as Anar and in Tamil as Madulai. The rinds of fruits are valued as astringents in diarrhea and dysentery. In folk medicine, dried pericarp of pomegranate preparations and the juice of the fruits are employed as an oral medication in the treatment of colic, colitis, leucorrhea, menorrhagia, oxyuriasis, paralysis and rectocele. This study deals with the pharmacognostic evaluation of the two variety of rind belong to punicaeae family which includes microscopic studies like transverse section of the rind. In conclusion in both the transverse section of the rind we observed the presence of epidermis, mesocarp, vascular strand and cuticle are seen.